Sensitivity analyses of linezolid against clinical gram-positive cocci isolates in vitro
- VernacularTitle:利奈唑胺对临床分离阳性球菌的体外敏感性分析
- Author:
Xiumei XIAO
;
Zhengying LIU
;
Xiaowei ZHANG
;
Jie ZHANG
- Publication Type:Journal Article
- Keywords:
linezolid;
vancomycin;
gram-positive cocci;
multidrug resistance;
sensitivity;
in vitro
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To compare the antibacterial activity of linezolid with vancomycin and other antibacterials against clinical gram-positive cocci isolates in vitro.METHODS: The antibacterial activity of linezolid and other antibacterials were determined according to the disk diffusion guidelines of NCCLS(CLSI) 2007 in vitro.RESULTS: The incidence of methicillin-resistant Staphylococcus aureus(MRSA) isolated in our hospital was 79.1%,linezolid showed great susceptibility as well as vancomycin and teicoplanin.The incidence of methicillin-resistant coagulase negative Staphylococcus(MRCNS,88.9%) was higher than that of MRSA,the antibacterial activity of linezolid was comparable with that of vancomycin and teicoplanin,and the sensitivity was 100%.The activity of linezolid against enterococcus faecalis is similar to that of vancomycin and teicoplanin,the activity of linezolid against enterococcus faecium is prior to that of vancomycin and teicoplanin(100%,80.4%,78.1%).Linezolid also showed great activity against penicillin resistant streptococcus pneumonia(PRSP).CONCLUSION: The antibacterial activity of linezolid was comparable with that of vancomycin and teicoplanin against MRSA,MRCNS,PRSP and enterococcus faecalis,and the sensitivity were all 100%.The antibacterial activity was better than those of the two drugs against enterococcus faecium in vitro.Linezolid could be a promising therapeutic option to treat infections caused by multi-resistant gram-positive cocci.
