Function of bombesin in reducing body temperature of febrile rats and its relativity with PGE_2
- VernacularTitle:蛙皮素对发热大鼠的降温作用及与PGE_2的相关性
- Author:
Liang ZHANG
;
Yanyang SU
;
Shufen ZHAO
- Publication Type:Journal Article
- Keywords:
fever;
bombesin;
interlukin-1?;
PGE_2
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effect of bombesin on body temperature thermothreshold.Methods With IL-1?-induced febrile rats as research subject,the content of PGE2 in hypothalamus and plasma was detected with radioimmunoassay.Results(1) Induced by i.c.v.injection of IL-1?(0.1 ?g),the content of PGE2 in hypothalamus and plasma of the febrile rats significantly increased(P
