The progress in TRPM8 research
- VernacularTitle:TRPM8的研究进展
- Author:
Jing DU
;
Licai ZHANG
- Publication Type:Journal Article
- Keywords:
TRPM8;
temperature sensing;
voltage-dependent gating;
tumor
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
TRP(transient receptor potential) ion channel is a kind of membrane proteins which are widespreadly present in various cells,which is used to identify various mixed flavor and warm,heat,cold,and other temperature.Originally cloned as a proatate-specific protein.TRPM8 is now best known as a cold-and menthol-activated channel implicated in thermosensation.We provide a brief review of current knowledge concerning the biophysical properties,gating mechanisms,pharmacology and(patho)physiology of this TRP channel.
