Effects of TRPV4 on LPS-induced fever,the content of cAMP and the concentration of [Ca~(2+)]i in rat hypothalamus
- VernacularTitle:在LPS致大鼠发热过程中下丘脑TRPV4对体温及cAMP含量、[Ca~(2+)]i浓度的影响
- Author:
Lanlan WANG
;
Le WANG
;
Yu CAO
- Publication Type:Journal Article
- Keywords:
fever;
TRPV4;
LPS;
[Ca~(2+)];
cAMP
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the effect of TRPV4 in thermoregulation.Methods We made the fever model with lipopolysaccharide in rat and used ruthenium red(RR) to inhibit the activity of TRPV4 to studied the content of TRPV4,cAMP and the concentration of [Ca2+]i.Result Given RR solely decreased the temperature Compared with LPS group,the increase amplitude of T,camp,[Ca2+]i all degrade in RR+LPS group And the content of TRPV4 are less than control group.Conclusion ① TRPV4 may participate the maintenance of normothermia;② The ferverscence was implemented by activating TRPV4 channel to induce a large calcium influx and then increasing the content of cAMP.
