The effects of pioglitazone on the adiponectin receptors expression of HUVECs induced by intermittent high glucose
- VernacularTitle:吡格列酮对波动性高糖处理的人脐静脉内皮细胞脂联素受体表达的影响
- Author:
Min ZHENG
;
Xiaoying LIU
;
Xiaohong LIU
;
Peizheng ZHENG
;
Libin LIU
- Publication Type:Journal Article
- Keywords:
pioglitazone;
intermittent high glucose;
HUVEC;
adiponectin receptor;
real-time PCR
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of pioglitazone on the AdipoR1 and AdipoR2 expression of HU-VECs induced by intermittent high glucose.Methods After exposed to intermittent high glucose for 5 d,HUVECs were incubated with pioglitazone(10,1 or 0.1 ?mol?L-1) for 24 hours.The AdipoR1 and AdipoR2 mRNA expression levels in HUVECs were also determined by real-time PCR.Results After exposed to intermittent high glucose for 5 days,HUVECs were treated with pioglitazone(10,1 or 0.1 ?mol?L-1) for 24 h.10,1?mol?L-1 of pioglitazone treatment enhanced AdipoR1 mRNA level(both P
