The Differential Expression of Hypothalamus Proteinum in PMS Liver-qi Invasion Mouse.
- VernacularTitle:经前期综合征(PMS)肝气逆证大鼠下丘脑蛋白差异表达
- Author:
Peng SUN
;
Huiyun ZHANG
- Publication Type:Journal Article
- Keywords:
Premenstral syndrome;
Liver-qi reversed symptom;
Hypothalamus;
Proteomics
- From:
Journal of Medical Research
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the differential expression of hypothalamus proteinum in PMS Liver-qi invasion mouse,in order to find the evidence on pathogenesis in protein level of PMS Liver-qi invasion.Methods The spectrum of a graph on hypothalamus protein of PMS liver-qi invasion symptom was analysed by two-dimensional gel electrophoresis,protein was identified by matrix-assisted laser desorption ionization time of flight mass spectrometry(MALDI-TOF-MS).Results Comparing model group with normal control group in hippocampus were as follows: Ubiquitin carboxy-terminal hydrolase L1,Albumin 1,Aldolase 3 were down-regulated;however M2 pyruvate kinase,ubiquinol-cytochrome creductase core protein I,Calbindin 2 were up-regulated,These protein were related to the function of ubiquitin iter、intermediary metabolism enzyme、compensation.Conclusion PMS Liver-qi invasion was related to the proteinum function of ubiquitin iter、intermediary metabolism enzyme、compensation,this results hint that this six protein were tight related with central pathogenesis of PMS liver-qi reversed symptom.
