The Analysis of Relationship Between Radiation Pneumonuitis and DVH for NSCLC Treated with 3DCRT.
- VernacularTitle:62例非小细胞肺癌三维适形放疗后放射性肺炎与剂量体积直方图分析
- Author:
Hekun JIN
- Publication Type:Journal Article
- Keywords:
NSCLC;
Radiotherapy;
Radiation pneumonitis;
Dose-volume-histogram
- From:
Journal of Medical Research
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the relation between the incidence of radiation pneumonitis(RP) and available parameters from a dose-volume histogram(DVH) in patients with non-small cell lung cancer(NSCLC) who underwent three-dimensional conformal radiotherapy treatment.Methods Between January 1998 and December 2005 our hospital,62 patients with NSCLC were treated using three-dimensional conformal radiotherapy(3D CRT).All patients were treated 5 days per week with daily fractionation of 2 Gy to total dose of 60~70 Gy.All patients were available for analysis for symptomatic RP.Radiation pneumonitis was graded according to the RTOG/EORTC morbidity scoring classification.Logistic regression analysis was performed to test the association between RP and the following DVH parameters: mean lung dose(MLD),volume of lung receiving 20 Gy(V20) and 30 Gy(V30) and normal tissue complication probability(NTCP).Additionally,correlation of the following clinical factors such as: age,sex,tumor site,performance status(KPS),and additional therapy(chemotherapy) with incidence of the RP were performed.Results Thirty out of 62 patients(48%) developed RP grade 0 or 1(0 grade:12%,1 grade:36%) and 32(52%) grade 2 or 3(2 grade:47%,3 grade:5%).In the logistic regression analysis,all DVH parameters were associated with RP(p in range from 0.004 to 0.007).The strongest association was observed for NTCP and V30(P=0.004).Conclusion NTCP and V30 parameters were the best predictors of symptomatic radiation pneumonitis for patients after three-dimensional conformal radiotherapy of non-small cell lung cancer.
