Effects of Helium-oxygen Mechanical Ventilation on Respiratory Mechanics and Oxygenation in ALI Animal Models.
- VernacularTitle:氦-氧机械通气对动物急性肺损伤模型呼吸力学和氧合作用的影响
- Author:
Xiongjian XIAO
;
Jiandong LIN
;
Guo LIN
- Publication Type:Journal Article
- Keywords:
Helium oxygen mixture;
Acute lung injury;
Breathing mechanics;
Oxygenation
- From:
Journal of Medical Research
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Helium-oxygen mechanical ventilation on respiratory mechanics and oxygenation in ALI animal models.Methods To investigate the changes of respiratory mechanics and oxygenated indexs in acute lung injury rat models caused by sepsis at different PEEP by comparing air-oxygen mixture mechanical ventilation with helium-oxygen mixture mechanical ventilation.Results 1.Helium-oxygen mechanical ventilation could not improve respiratory mechanical indexs in ALI animal models(airway peak pressure、mean airway pressure、platform pressure、dynamic compliance、airway resistance、flow rate of peak value).On the contrary,in the condition of high level of PEEP,some indexs became worse,such as depress of dynamic compliance(P
