Propofol protects Rhesus macaques from reperfusion lung injury
- VernacularTitle:异丙酚对猕猴再灌注肺损伤的保护作用机制
- Author:
Mingjun WANG
;
Qing SONG
;
Hong ZHANG
;
Weidong MI
- Publication Type:Journal Article
- Keywords:
propofol;
shock, hemorrhagic;
lung injury;
pathology
- From:Journal of Third Military Medical University
2003;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find out the cause of lung injury due to hemorrhagic shock and resuscitation, and the mechanism of propofol protecting Rhesus macaques from lung injury. Methods Twelve healthy Rhesus macaques were randomly divided into two groups: propofol group and control group. The animal model was made by 2-hour hemorrhagic shock and 2-hour resuscitation. Rhesus macaques in propofol group were given propofol at a plasma concentration of 8 mg/L all through by the technique of target controlled infusion. Hemodynamic parameters, gas analysis and RBC, WBC, HB and PLT contents from collected arterial blood were respectively determined before bleeding, 2 h after hemorrhagic shock and 2 h after resuscitation. Results Mean pulmonary arterial pressure and pulmonary vascular resistance index in propofol group 2 h after hemorrhagic shock and 2 h after resuscitation were significantly lower than those in control group (P
