Interaction of fluorine,calcium and iodine in anti-oxidation capability of thyroid gland in rats
- VernacularTitle:氟、钙、碘对大鼠甲状腺抗氧化能力的交互作用观察
- Author:
Yan ZOU
;
Xubo SHEN
;
Jianhua WANG
- Publication Type:Journal Article
- Keywords:
fluorine;
calcium;
iodine;
thyroid gland;
interaction
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the interactive effects of fluorine,calcium and iodine on thyroid SOD,CAT and MDA of rats.Methods Based on 2?2?2 factorial design,80 Wistar rats were randomly divided into 8 groups and diet with different ingredients: ① moderate concentrations of fluorine(F),calcium(Ca) and iodine(I)(NF,NCa,NI);② moderate concentrations of F,I and high concentration of Ca(NF,NI,HCa);③ moderate concentrations of Ca and I and high concentration of F(NCa,NI,HF);④ moderate concentration of I and high concentrations of F and Ca(NI,HF,HCa);⑤ moderate concentrations of F and Ca and low concentration of I(NF,NCa,LI);⑥ moderate concentration of F,high concentration of Ca and low concentration of I(NF,HCa,LI);⑦ moderate concentration of Ca,high concentration of F and low concentration of I(NCa,HF,LI);and ⑧ high concentrations of F and Ca and low concentration of I(HF,HCa,LI).The moderate concentration of F was 90?g/d,and the high concentration of F was 30 times that of moderate concentration.The moderate concentration of Ca was 13mg/d,the high concentration of Ca was 20 times that of moderate concentration.The moderate concentration of I was 3.5?g/d,i.e.15 times that of low concentration.After six months,the activities of SOD and CAT,and the content of MDA in the thyroid were determined by xanthine oxidase method,visible spectrophotometry and colorimetry.Results According to the results of factorial ANOVA,the significant interaction of F with I on SOD was found(F=3.97,P=0.05).The activity of SOD in ⑤ group was significantly higher than that in ① group(t=2.36,P=0.03).The activity of SOD in ⑥ group was higher than that in ② group(t=-3.04,P=0.01).The activity of SOD in ⑧ group was lower than that in ⑦ group(t=2.36,P=0.03).The activity of SOD in ④ group was higher than that in ② group(t=-2.91,P=0.01).A significant interaction of fluorine,calcium with iodine to CAT was found(P
