Mechanism study on Dahuangzhechong pill antiplatelet activation
- VernacularTitle:大黄虫丸抗血小板活化的机制研究
- Author:
Dongsheng WANG
;
Fangping CHEN
;
Shilin HE
;
Changjiang XIAO
;
Faqing TANG
- Publication Type:Journal Article
- Keywords:
Dahuangzhechong pill;
Platelet activation;
Arterial thrombosis
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the inhibitory effect of Dahuangzhechong pill to platelet activation.Methods: The blood platelet were incubated with the medicated blood plasma with Dahuangzhechong pill,and then activated with ADP and marked with PAC-1 monoclonal antibody.The activation rate of blood platelet was analyzed by flow cytometer.The patients with coronary heart disease or cerebral infarction took Dahuangzhechong pill,after one course of treatment,the patients,blood platelet were separated and then incubated with PAC-1 monoclonal antibody.The activation of blood platelet was detected by ? ow cytometer.Results: Compared with aspirin group(51.7%),the activation rate(20.82%) of blood platelet in Dahuangzhechong pill group decreased(P
