Effect of Kechuanning on expression of NF-?B in lung tissue of bronchial asthmatic rats
- VernacularTitle:咳喘宁对支气管哮喘大鼠肺组织NF-?B表达的影响
- Author:
Muxiang YANG
;
Wentao YU
;
Huazhou XU
;
Xiaohong WANG
;
Jiewen YANG
- Publication Type:Journal Article
- Keywords:
Kechuanning;
Bronchial asthma;
Nuclear factor ?B
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe effect of Kechuanning on expression of nuclear factor kB(NF-?B) in lung tissue of bronchial asthmatic rats.Methods: 40 rats were randomly divided into 5 groups: the normal group,the model group,Kechuanning high-dose group(27g/kg),Kechuanning low-dose group(13.5g/kg),GuilongKechuanning control group(0.45g/kg),8 rats in each group.The bronchial asthmatic model was established by egg protein sensibilization and long-term inhalation provocation.The rats of each treatment groups were lavage administration each day from the first time of provocation to execution.After 4 weeks of treatment,the rats were killed and lung tissue were taken to dyeing of HE to be observed.The expression of NF-?B in lung tissue were determined by immunohistochemistry.Result: Compared with the normal group,the thickness of bronchus wall and bronchus smooth muscle,the numbers of eosinophile granulocyte and leukomonocyte,and expression of NF-?B in lung tissue were increased in the model group(P
