Effects of valsartan on the expression of acyl-coenzyme A:cholesterol acyltransferase-1 and peroxisome proliferator activated receptor-gamma in experimental atherosclerosis in rabbits
- VernacularTitle:缬沙坦对兔动脉粥样硬化斑块中ACAT-1和PPAR-?表达的影响
- Author:
Zhiqiang MA
;
Bei CHENG
;
Yuhui DING
- Publication Type:Journal Article
- Keywords:
arteriosclerosis;
valsartan;
acyl-coenzyme A: cholesterol acyltransferase-1;
peroxisome proliferator activated receptor ?
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of valsartan on the expression of acyl-coenzyme A: cholesterol acyltransferase-1(ACAT-1) and peroxisome proliferator activated receptor-gamma(PPAR-?) in atherosclerotic plaques on rabbit aortic wall.Methods Twenty-four male Japanese white rabbits were randomly assigned into three groups(8 each): control group,valsartan group and high cholesterol feeding group.All rabbits were fed according to the experimental protocol for 12 weeks.Blood samples were taken from vein for measurement of serum lipids.The ratio of intima/media thickness of the aorta was measured.ACAT-1 mRNA/protein and PPAR-? mRNA/protein were determined by reverse transcription polymerase chain reaction(RT-PCR) and Western blotting,respectively.Results After 12 weeks,the levels of serum total cholesterol(TC),triglyeride(TG) and low density lipoprotein-cholesterol(LDL-C) in valsartan group and cholesterol group were significantly higher than those in control group(P0.05).The intima thickness and the ratio of intima/media in carotid arteries in cholesterol group were significantly higher than those in control group and valsartan group(P
