Determination of the ED_(50) of spinal anesthesia 0.75% ropivacaine for cesarean section
- VernacularTitle:剖宫产时蛛网膜下隙0.75%罗哌卡因麻醉的ED_(50)
- Author:
Xiaoshu SHEN
;
Guo GAN
;
Liyong YUAN
- Publication Type:Journal Article
- Keywords:
cesarean section;
combined spinal-epidural anesthesia;
ropivacaine;
median effective dose
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To determine the median effective dose(ED50) of spinal anesthesia 0.75% ropivacaine for cesarean section. METHODS: Thirty-two ASAⅠ-Ⅱ parturients undergoing elective cesarean section delivery with use of combined spinal-epidural anesthesia were enrolled in this study. The initial dose of was 12.8 mg of 0.75% ropivacaine, and the dosing intervals were 98.4% of the preceding dosage. Doses for subsequent parturients were determined by the response of the previous parturient. Successful anesthesia was defined as a loss of sensation to an acupuncture stimulus at the T7 level, full motor blockade within 10 minutes after administration of the local anesthetic, analgesia of incision and the satisfaction of skelaxin evaluated by one operator. ED50 and its 95% confidence interval (CI) was determined with use of Dixon method. RESULTS: Five parturients were rejected out the study because of doubtful anesthsia. According to the rest twenty-seven parturients' data, the ED50 of intrathecal 0.75% ropivacaine was 11.97 mg (95% confidence interval [CI], 11.75-12.19 mg). CONCLUSION: The ED50 of spinal 0.75% ropivacaine for cesarean delivery under the conditions of this study were 11.97 mg.
