Research advance on the characteristics and application of CYP450 metabolic enzymes
- VernacularTitle:CYP450酶特性及其应用研究进展
- Author:
Xiaoyu LI
;
Gaolin LIU
- Publication Type:Journal Article
- Keywords:
drug metabolic enzyme;
cytochrome P450;
drug treatment;
new drug investigation
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Cytochrome P450 is an important kind of enzymes for the metabolism of drug and other endo-or xeno-biotics. Classification of metabolic enzymes, molecular biological characteristic of CYP3A4, CYP2D6, CYP2C9, CYP2C19, CYP2E1, CYP1A2 and CYP2A6 were described in this review. Influence of traditional Chinese medicine(TCM) on metabolic enzyme and its application in clinical drug therapeutics and drug development were also reviewed in this article.
