Effect of Puerarin on the Apelin and its receptor of lung tissue in chronic hypoxia-hypercapnia rats
- VernacularTitle:葛根素对低O_2高CO_2肺动脉高压大鼠肺组织中Apelin及其受体的影响
- Author:
Yanfan CHEN
;
Xiaofang FAN
;
Yongsheng GONG
;
Shaoxian CHEN
- Publication Type:Journal Article
- Keywords:
puerarin;
Apelin;
receptor;
hypoxia;
hypercapnia;
pulmonary hypertension
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the effects of Puerarin on the Apelin and its receptor APJ of lung tissue in rats with hypoxia pulmonary hypertension.Methods Thirty SD rats were randomly divided into normal control group(N),and hypoxia hypercapnia group(F),and hypoxia hypercapnia+Puerarin group(P).The levels of Apelin-36 in serum and in lung tissue were measured by radioimmunity,the expressions of Apelin and APJ in pulmonary tissuse were observed by RT-PCR.Results ①Mean pulmonary arterial pressure(mPAP),weight ratio of RV to LV+S,the levels of Apelin in serum and in lung tissue of group F were significantly higher than those of group N(P
