Effects of ClC-3 chloride channel on the Ca~(2+) movement induced by Thapsigargin in PC12 cells
- VernacularTitle:ClC-3氯通道对Thapsigargin触发的Ca~(2+)运动的影响
- Author:
Haining ZHANG
;
Qinying QIU
;
Yongyuan GUAN
- Publication Type:Journal Article
- Keywords:
ClC-3 chloride channel;
overexpression;
Ca2+;
Thapsigargin
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).SK & F96365 at the concentration of 5～20 ?mol?L-1 inhibited the Ca2+ influx induced by 1.0 ?mol?L-1 Thapsigargin in a concentration-dependent manner.The inhibitory effect of SK & F96365 on Ca2+ influx was decreased by overexpression of ClC-3 protein.Conclusion ClC-3 chloride channel was involved in the regulation of store-operated Ca2+ entry(SOCE).
