C-Jun N-terminal kinase pathway and neurodegenerative disease
- VernacularTitle:JNK信号通路与神经退行性疾病
- Author:
Jing PAN
;
Shengdi CHEN
- Publication Type:Journal Article
- Keywords:
neurodegenerative disorders;
JNK;
therapy;
target
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
c-Jun N-terminal kinases(JNKs)play an integral role in neuronal death in multiple cell lines following a wide variety of stimuli and in a number of physiological functions which have been recognized as important enzymes in cellular function.JNK has been implicated in several neurodegenerative diseases.Data are emerging to extend the understanding of the JNK signaling and confirm the possibility that targeting JNK signaling may offer an effective therapy for pathological conditions in the near future.Because of the involvement of JNK in neuronal diseases,the inhibition of this enzyme is an attractive therapeutic target.
