Research progress in the effects of nonsteroidal anti-inflammatory drug on Alzheimer's disease
- VernacularTitle:非甾体类抗炎药抗阿尔采末病作用的研究进展
- Author:
Lina HAO
;
Qingzhu ZHANG
;
Tiangui YU
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
nonsteroidal anti-inflammatory drugs;
cyclooxygenase;
?-amyloid peptide;
peroxisome proliferator-activated receptor-?
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Neuroinflammation may be one of the causes in the pathogenesis of Alzheimer's disease(AD).Epidemiological studies suggest that long-term use of nonsteroidal anti-inflammatory drugs(NSAIDs)can reduce the risk of AD.Laboratory evidence indicates that the protection of NSAIDs is mediated by inhibition of cyclooxygenase(COX)activity and the non-COX mechanisms.This review summarizes the possible underlying mechanisms in the action.
