EFFECTS OF PSYCHOLOGICAL STRESS ON LEVELS OF HOMOCYSTEINE AND FOLATE IN RATS AND REGULATION OF FOLATE
- VernacularTitle:心理应激对大鼠叶酸和同型半胱氨酸的影响及补充叶酸的调节作用
- Author:
Yue HOU
;
Yan HONG
;
Weiqiang CHEN
;
Shutian LI
;
Donglan WANG
;
Yiyong CHENG
- Publication Type:Journal Article
- Keywords:
homocysteine;
psychological stress;
folate
- From:
Acta Nutrimenta Sinica
1956;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of psychological stress on the levels of Hcy and folate in rats. Method The Wistar rats were randomly assigned to three groups as follows:control,stress and stress with folate supplement. The animal model of psychological stress was developed by restraint. Results The levels of Hcy both in plasma and cerebrospinal fluid were increased and not only the level of folate in plasma but also in cortex,hippocampus,liver and mucous membrane epithelium of small intestine were decreased under restraint stress. Folate supplement could improve the depletion of folate and the increase of Hcy induced by restraint. Conclusion The depletion of folate may be one of the important factors of high Hcy level induced by psychological stress.
