Effect of Ambroxol on Contents of PMN,TNF-?,IL-6 and IL-8 in Bronchoalveolar Lavage Fluid after Closed Circuit Anesthesia in Infants
- VernacularTitle:氨溴索对循环紧闭全麻婴儿支气管肺泡灌洗液中PMN、TNF-?、IL-6及IL-8含量的影响
- Author:
Xiaoshu SHEN
;
Liyong YUAN
;
Guo GAN
;
Xiamin WANG
- Publication Type:Journal Article
- Keywords:
Ambroxol hydrochloride;
Infant;
Closed circuit anesthesia;
Bronchoalveolar lavage fluid;
Polymorphonuclear neutrophil leukocyte;
Tumor necrosis factor;
Interleukin-6;
Interleukin-8
- From:
Journal of Medical Research
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ambroxol administered before surgery on contents of PMN,TNF-?,IL-6 and IL-8 in bronchoalveolar lavage fluid after closed circuit anesthesia in infants.Methods 40 infants who practiced selective orthopedics or abdominal operations were randomly divided into ambroxol group (group A) and control group (group B). Two days before operation,infants in group A and group B were administed ambroxol 0.3 mg/kg or 0.9 normal saline 10 ml through intravenous injection three times per day,respectively .The last single dose was administered before anesthesia induction.The bronchoalveolar lavage fluid of intants were collected immediately after tracheal intubation(T1) and before tracheal extubation(T2),respectively.Interleukin-6 and interleukin-8 in the bronchoalveolar lavage fluid were determined by enhancement solid-phase enzyme immunoassay action(EASIA),and TNF-? in the bronchoalveolar lavage fluid by euzymelinked immunosorbent assay (EIA).The numbers of polymorphonuclear neutrophils in the bronchoalveolar lavage fluid were examined. The contents of PMN,TNF-?,IL-6 and IL-8 in two groups were compared .The time of analepsia and complications of respiratory tract were observed after operation.Results Compared with group A, the contents of PMN,TNF-?,IL-6 and IL-8 in BALF collected at T2 were significant higher in group B (P
