Expression of KAI1, Intergrin ?5?1and FAK Proteins in Lung Cancer and Their Biological Significances
- VernacularTitle:穿膜蛋白KAI1与intergrin?5?1、FAK在肺癌组织中的表达及其临床意义
- Author:
Ting LIU
;
Chunqing ZHANG
;
Xinyun WANG
- Publication Type:Journal Article
- Keywords:
Lung cancer;
KAI1;
Intergrin?5?1;
FAK;
Protein expression;
Diagnosis
- From:
Journal of Medical Research
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of KAI1, intergrin ?5?1 and FAK proteins in occurrence and development and invasion and metastasis of lung cancer and their value in predicting the prognosis of lung cancer by analyzing the expression levels of KAI1, intergrin ?5?1 and FAK proteins in lung cancer and the relationship between them and clinicopathological parameters.Methods Lung cancer and normal lung tissue and metastasis cancer were detected and analyzed for their KAI1, and FAK protein level using immunobiochemical method. Results The positive rate of KAI1 in normal tissue, primary cancer and metastasis cancer was respectively 100.0, 24.7 and 0.0. The positive rate of intergrin?5?1 was respectively 0.0, 49.4 and 83.3. The positive rate of FAK was respectively 10.0,48.3 and 83.3. The difference of above three marker among three groups was significant (P
