Effects of Shengmai Injection on Tumor Growth and the Expression of P-gp in Transplanted Tumor of Human Gastric Carcinoma of SGC7901/VCR Cell in Nude Mice
- VernacularTitle:生脉注射液对裸鼠人胃癌SGC7901/VCR细胞移植瘤生长及P-gp表达的影响
- Author:
Shulan HAO
;
Likun LIU
;
Yifang LI
;
Xinwen WANG
;
Lifang YANG
- Publication Type:Journal Article
- Keywords:
Starmach neography;
Multidrug resistance;
Shengmai injection;
Nude;
Mice
- From:
Journal of Medical Research
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of Shengmai Injection on tumor growth and the expression of P-gp in transplanted tumor of human gastric carcinoma of SGC7901/VCR cell in nude mice.Methods Transplanted tumor model of human gastric carcinoma of SGC7901/VCR cell in nude mice was built, which was divided randomly into five groups: normal saline control-group, 5-FU group, 5-FU + verapamil group, 5-FU +Shengmai group, Shengmai group. Nude mice growth state was observed, average weigh and inhibition rate of transplanted tumor were calculated, and the expression of P-gp was detected.Results There was significanf difference in terms of transplanted tumor weight,volume among 5-FU+Shengmai group and 5-FU group and normal saline group(P0.05); P-gp express had difference between normal saline group and shengmai group, P
