Clinical Significance of Micrometastasis Detection in Conventional Pathologic Nonmetastasis Lymph Nodes of Patients with Breast Cancer
- VernacularTitle:乳癌阴性淋巴结微转移检测的临床意义
- Author:
Hua RUAN
;
Guizhen ZHANG
;
Luoyun WEI
;
Qingping XIA
;
Mingcheng WANG
- Publication Type:Journal Article
- Keywords:
Breast tumor;
Lymphatic metastasis;
Micrometastasis detection;
CK;
EMA;
CEA
- From:
Journal of Medical Research
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between lymph node micrometasis and clinicopathological parameters.Methods Immunohistochemical method was adopted to detect cytokeratin pan(CK)、Epithelial Membrane Antigen(EMA) and Carcinoembryonic Antigen(CEA) in 389 lymph nodes from 36 cases of breast cancer, in which conventional pathological diagnosis showed no lymph node metastasis.Results Micrometastasis was found in 38 lymph nodes (9.2) of 12 cases (33.3) .The incidence of micrometasis was correlated with tumor size. Pathological diagonosis and metastasis lymph nodes. Conclusion Micrometastasis detection in negative lymph nodes of breast cancer is recommended to precisely determine the tumor stage, in order to direct cancer therapy and predict prognosis.
