Expressions of VEGF and TNF-? in interspinous ligament of patients with ankylosing spondylitis in active stage
- VernacularTitle:强直性脊柱炎活动期VEGF和TNF-?在棘间韧带组织中mRNA表达水平的检测
- Author:
Yiming QIAN
;
Tongwei CHU
;
Jianming LI
;
Yugang LIU
- Publication Type:Journal Article
- Keywords:
ankylosing spondylitis;
TNF-?;
VEGF;
hybridization in situ
- From:Journal of Third Military Medical University
2003;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the pathological expressions of TNF-? and VEGF in interspinous ligament of patients with ankylosing spondylitis(AS) in active stage. Methods The expressions of TNF-? mRNA and VEGF mRNA in the interspinous ligament of patient with AS group and control group were detected by hybridization in situ. Their different results were compared by image analysis system and the correlation between TNF-? mRNA, VEGF mRNA and both AS disease active index (DAI) and C reactive protein (CRP) was analysed respectively. Results The expressions of TNF-? mRNA and VEGF mRNA in the interspinous ligament of patients with active AS were positive,but those of the control group were negtive. Statistical differences existed in the positive cell numbers and in image gray scale value of AS group (P
