Effects of HYAL1 gene overexpression on invasive,angiogenic and proliferative ability of breast cancer cells
- VernacularTitle:HYAL1基因过表达对乳腺癌细胞迁移能力和血管生成能力及增殖的影响
- Author:
Xinliang SU
;
Guosheng REN
;
Xiaoyi WANG
;
Jinxiang TAN
- Publication Type:Journal Article
- Keywords:
breast cancer;
hyaluronidase;
invasion;
angiogenesis;
proliferation
- From:Journal of Third Military Medical University
2003;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of HYAL1 gene overexpression on invasive, angiogenic and proliferative ability of breast cancer cell lines MCF-7 and ZR-75-30. Methods Double-chamber co-culture technique was applied to construct the invasive model and angiogenic model in vitro, which was used to detect the invasive and angiogenic potential of breast cancer cell; MTT and flow cytometry were used to detect the proliferation of breast cancer cells. Results Breast cancer cells overexpressing HYAL1 gene showed stronger invasive potential and angiogenic potential than control cells, but had no significant difference on proliferative potential. Conclusion Overexpression of HYAL1 gene can promote the invasion and angiogenesis of breast cancer cells in vitro, but not affect the proliferation.
