Association between cytochrome P450 3A4 gene 894C>T single nucleotide polymorphism and clopidogrel resistance
- VernacularTitle:细胞色素P450 3A4 894C>T位点基因多态性与氯吡格雷抵抗的关系
- Author:
Yaling HAN
;
Xiaoyan MAI
;
Yi LI
- Publication Type:Journal Article
- Keywords:
clopidogrel resistance;
polymorphism,single nucleotide;
cytochrome P450 3A4
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
T was genotyped by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)in all the patients.Results The occurrence of CR in this population was 23.3%(70/300).There was CYP3A4 894C/T polymorphism in the study population.The frequencies of the three kinds of genotypes(CC,CT,TT)in CR group and non-CR(NCR)group were 45.7%,50.0%,4.3% and 63.5%,31.7%,4.8%,respectively.The frequency of TT genotype was significantly higher in NCR group than that in CR group(OR=2.06,95% CI:1.201-3.547,P=0.020).C allele carriers were more likely to develop clopidogrel resistance compared with that of T allele carriers(OR=1.59,95% CI:1.037-2.442,P=0.023).Conclusion CYP3A4 gene 894C/T polymorphism is associated with the risk of CR,and C allele carriers may be a possible genetic susceptibility factor for patients with CR.
