Lymphocytic Hypophysitis with Diabetes Insipidus: Improvement by Methylprednisolone Pulse Therapy.
- Author:
Young Suk JO
1
;
Hyo Jin LEE
;
So Young RHA
;
Woo Jung HONG
;
Chang June SONG
;
Young Kun KIM
;
Heung Kyu RO
Author Information
1. Division of Endocrinology, Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea. rohkyu@hanbat.chungnam.ac.kr
- Publication Type:Case Report
- Keywords:
Lymphocytic hypophysitis;
Diabetes insipidus;
Methylprednisolone
- MeSH:
Anti-Inflammatory Agents/*administration & dosage;
Diabetes Insipidus/*drug therapy/etiology;
Female;
Humans;
Lymphocytosis/complications/*drug therapy;
Methylprednisolone/*administration & dosage;
Middle Aged;
Pituitary Diseases/complications/*drug therapy;
Pulse Therapy, Drug
- From:The Korean Journal of Internal Medicine
2004;19(3):189-192
- CountryRepublic of Korea
- Language:English
-
Abstract:
Lymphocytic hypophysitis is a rare inflammatory disorder in the pituitary gland. The lesion is usually confined to the adenohypophysis. Although the involvement of the posterior pituitary gland or the stalk is rare, such patients with diabetes insipidus have been reported. Surgery has been used to make the definitive diagnosis. Recent studies suggest, however, that the pathologic diagnosis may not be necessary always. We reported a case of Lymphocytic hypophysitis managed by methylprednisolone pulse therapy. A 50-year-old premenopausal woman with Lymphocytic hypophysitis and diabetes insipidus was treated with methylprednisolone pulse therapy. Her adenopituitary lesion disappeared and the diabetes insipidus resolved. The optimal management for patients with lymphocytic hypophysitis may be the high index of the suspicion prior to the extensive surgical resection. In addition, methylprednisolone pulse therapy may improve the clinical and MRI findings.
