Signif icance of expression of VEGF in lung cancer tissues and interference of Shiquan Dabu Decoction in it
- VernacularTitle:血管内皮细胞生长因子在Lewis肺癌组织中表达的意义及十全大补汤对其干预作用
- Author:
Hong SONG
;
Suzhen BAO
;
Xiaowei ZHENG
;
Ying WANG
;
Yongjun ZHANG
- Publication Type:Journal Article
- Keywords:
VEGF Shiquan Dabu Decoction;
Immunohistochemistry
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the intervention of Shiquan Dabu Decoction (SQDBD) in the protein expression of VEGF. Methods: 50 C57BL/6 mice inoculated with lewis lung cancer were randomly divided into five groups and treated by different drugs. The ratio of antitumorand and antimetastatic of each group were calculated after 15 days’ treatment. The expression of VEGF was detected by SABC immunohistochemical method. Results: Low, medium and high dosages of SQDBD had the function of antitumor and antimetastusi at different extent. SQDBD could inhibit the positive expression of VEGF protein. Conclusion: Inhibition of the expression of VEGF protein is possibly one of the mechanisms of SQDBD in antitumor.
