A study on abnormality of coagulation and fibrinolytic system in patients with COPD at acute stage
- VernacularTitle:慢性阻塞性肺疾病急性期凝血纤溶系统功能变化的临床研究
- Author:
Liyu LI
;
Chen WANG
;
Baosen PANG
;
Yuanhua YANG
- Publication Type:Journal Article
- Keywords:
COPD;
coagulation;
fibrinolysis
- From:
Chinese Journal of Practical Internal Medicine
2002;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss possible mechanism of chronic obstructive pulmonary disease(COPD)coagulation and fibrinolysis dysfunction.Methods Totally 47 healthy controls(Group A)and 38 cases of AECOPD(Group B)were chosen respectively.The plasma levels of vWF,Factor Ⅹ,TF,TFPI,TM,PC,tPA,PAI-1 and D-dimer were measured by ELISA method,and the blood AT-Ⅲ activity was measured by chromogenic assay.The cases of Group B were measured for RBC,WBC,PLT,PH,PaO2,PaCO2,HCO-3,PT,APTT,FBG,and so on.Results The plasma levels of vWF,TF,Factor Ⅹ,t-PA and D-dimer in Group B were significantly higher than those in Group A while TM and PC were significantly lower in Group B(P
