Effects of telmisartan on cognition and GHSR expression in frontal cortex of diabetic rats
- VernacularTitle:替米沙坦对糖尿病大鼠认知功能及大脑皮质Ghrelin受体表达的影响
- Author:
Haina ZHANG
;
Yuan GAO
;
Qinan WU
;
Qian XIAO
- Publication Type:Journal Article
- Keywords:
telmisartan;
diabetes;
growth hormone secretagogues receptor;
cognitive ability
- From:Journal of Third Military Medical University
2003;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of telmisartan on cogtive function and the expression of Ghrelin receptors,growth hormone secretagogues receptor(GHSR) in diabetic rats. Methods Forty rats were randomly divided into 3 groups: control group,diabetic model group,and telmisartan treatment group. Streptozotocin-induced diabetic rat model(65 mg/kg,ip) was established. In the telmisartan treatment group,the rats were treated with telmisartan (13.3 mg?kg-1?d-1) for 12 weeks. Learning and memory abilities of the rats were tested by the Morris water maze. The mRNA and protein levels of GHSR in frontal cortex were detected by RT-PCR and immunohistochemistry. Results Compared with the diabetic model group,the telmisartan treatment group showed a significant decrease in the mean time of escape latencies(P
