Allosteric regulation of G-protein coupled receptors
- VernacularTitle:G蛋白偶联受体变构调节作用的研究进展
- Author:
Nan MOU
;
Liyun WANG
;
Jianquan ZHENG
- Publication Type:Journal Article
- Keywords:
GPCRs;
allosteric regulation
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Despite the important properties of GPCRs as drug targets,improving the subtype selectivity and efficiency of new drugs targeting at GPCRs is a predominant challenge.The study of GPCRs allosterism shows there exist great complexity and diversity in allosterism and allosteric sites,and it also provides a new opportunity for exploring new drugs with subtype selectivity and efficiency.This review summaries the development of GPCRs allosterism in recent years and shows GPCRs allosterism and its biological significance.
