The protective effect of pentoxifylline on myocardium injury induced by ischemia-reperfusion and Ca~(2+) paradox
- VernacularTitle:己酮可可碱对大鼠离体心脏缺血/再灌注及缺钙/复钙损伤的保护作用
- Author:
Ming ZHANG
;
Xiaoyan L
;
Haiying ZHANG
;
Chunmei WANG
;
Li CHEN
- Publication Type:Journal Article
- Keywords:
pentoxifylline;
ischemia-reperfusion;
Ca~(2+) paradox
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the protective effect of pentoxifylline on myocardium injury induced by ischemia-reperfusion.Methods Heart ischemia-reperfusion model was induced in the isolated rat hearts subjected to 30 min ischemia and 30 min reperfusion.70 Wistar rats were divided randomly into seven groups: control group,ischemia-reperfusion group,four dose pentoxifylline treatment groups(50,100,125,150 ?mol?L-1) and post ischemia pentoxifylline treatment group.The intracellular Ca2+-overload was induced in the isolated rat hearts subjected to 5 min Ca2+-depletion and 30 min Ca2+-repletion(Ca2+-paradox).30 Wistar rats were divided randomly into three groups(control group,Ca2+-paradox group and pentoxifylline treatment group).Hemodynamics data were recorded.Results Reperfusion of the ischemic heart resulted in impaired cardiac performance.These alterations in cardiac function were attenuated by treatment of the heart with 100 ?mol?L-1 pentoxifylline(P
