Establishment of and Effects of BPV on Experimental Allergic Encephalomyelitis in Lewis Rats
- VernacularTitle:Lewis大鼠实验性变态反应性脑脊髓炎动物模型的建立及百日咳疫苗的影响
- Author:
Zhenguo ZHU
;
Rongyuan ZHENG
;
Jianmin LI
;
Zhao HAN
- Publication Type:Journal Article
- Keywords:
Experimental allergic encephalomyelitis;
Bacille calmette guerin;
Complete Freund's adjuvant;
Bordetella pertussis vaccine
- From:
Journal of Medical Research
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the animal model of experimental allergic encephalomyelitis(EAE)in Lewis rats.Methods The EAE was induced by giving hypodermal injections in feet with spinal cords homogenate of guinea pigs(GPSCH)and complete Freund's adjuvant(CFA)containing 8mg.ml-1 bacille calmette guerin(BCG).The EAE model was evaluated by clinical manifestations and pathologic findings which was studied with the aid of light and electron microscope.Results The EAE in Lewis rats had an incidence of 9/10,a latency of 12.6?1.01d.Bordetella pertussis vaccine(BPV)could increase the morbidity,shorten the latency(P
