Interference of Cilostazol to Aspirin Resistance in Patients with Coronary Heart Disease
- VernacularTitle:西洛他唑对冠心病患者阿司匹林抵抗的干预作用
- Author:
Haifeng LIANG
;
Xinhua LIU
- Publication Type:Journal Article
- Keywords:
Cilostazol;
Aspirin resistance;
Coronary heart disease;
2-diabetes mellitus;
Platelet aggregation rate
- From:
Journal of Medical Research
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of cilostazol to aspirin resistance in patients with coronary heart disease.Methods A total of 165 patients with coronary heart disease were set apart two groups:group A:coronary heart disease,group B:coronary heart disease by 2-diabetes mellitus,Both group A and group B received 100 mg of aspirin daily for 7 days and no other antiplatelet agent.The blood samples were analyzed by platelet aggregation(PAG)test.Platelet aggregation using adenosine diphosphate(ADP)and arachidonic acid(AA).then two groups were randomized four groups:A1,A2,B1,B2 separately.both group A1 and B1received aspirin 100 mg qd continuely,group A2 and B2 added anther antiplatelet drug cilostazol 50 mg bid,redetected platelet aggregation after a week.compared PAG and AR using statistic methods.Results PAG and AR of group A is lower than group B(P0.05).The PAG and AR of group A2 was significantly lower than group A and group A1(P0.05),the PAG and AR of group B2 is significantly lower than group B and group B1(P
