The Association between the Polymorphism of hURAT1 Gene Exon 1 C258T and the Metabolism Syndrome
- VernacularTitle:人阴离子交换器(hURAT1)基因多态性与代谢综合征的关系
- Author:
Bo WANG
;
Shaohua SUI
;
Wenjuan ZHANG
;
Changhua QU
- Publication Type:Journal Article
- Keywords:
Metabolism syndrome;
Gene;
Polymorphism
- From:
Journal of Medical Research
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of the polymorphisms of hURAT1gene in exon 1 C258T and the compnents of metabolism syndrome.Methods This research is divided into the hyperuricemia groop(138 examples)and the healthy matched controls(117 examples),which selected of the two groops were determined body high,body medical history;They were checked blood uric acid,fasting blood glucose,blood-fat,hepatic enzyme,urea nitrogen and blood creatinine.Analysis the polymorphisms of hURAT1 gene in exon 1 C258T by polymerase chain reaction technique.Investigate the dependablity beween the blood uric acid,fasting blood glucose,systolic blood pressure,diastolic blood pressure,total chloesterol,triacylglycerol,body mass index,waistline,rump circumference and the different genetypes.Results The differences have statiscal significance in UA,SBP,DBP,TC,TG,BMI,WHR beween the CC genetype and the CT genetype(P
