The Impact of Leukocyte-removed Priming Fluid on Plasma Inflammatory Factors TNF-?,IL-6,IL-8,NE peri-cardiopulmonary Bypass in Infants
- VernacularTitle:去白细胞血预充对婴儿体外循环血浆TNF-?、IL-6、IL-8和NE的影响
- Author:
Luyan GAO
;
Zimin CHEN
;
Zijian LIU
;
Tao WANG
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass;
IL-6;
IL-8;
TNF-?;
NE;
White blood cel
- From:
Journal of Medical Research
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of leukocyte-removed priming fluid on plasma inflammatory factors TNF-?,IL-6,IL-8,NE peri-CPB in infants.Methods Selected 60 infants,of less than 1-year-old,with ventricular septal defect(VSD)were randomly assigned to the experimental group and the control group.The experimental group took blood leukocyte-removed priming fluid,and the control group took banked blood-derived priming fluid.The plasma TNF-?,IL-6,IL-8,NE concentrations were determinated by using ELISA at the corresponding period of cardiopulmonary bypass(before CPB,aortic cross-clamping 10 min,aortic open 10 min,2h,6h,12h,24h and 48 h after the end of CPB).Results TNF-?,IL-6,IL-8,NE concentrations increased significantly after the start of CPB(P
