Enteral fish oil immunonutrition prevents pulmonary dysfunction during intra-abdominal sepsis and hypertension in rats
- VernacularTitle:鱼油对腹腔感染并发腹腔高压大鼠肺功能的保护作用
- Author:
Zheng LOU
;
Jieshou LI
- Publication Type:Journal Article
- Keywords:
Intra-abdominal sepsis;
Intra-abdominal hypertention;
Lung;
Fish oil;
Cytokines
- From:
Parenteral & Enteral Nutrition
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether an enteral fish oil immunonutrition during intra-abdominal sepsis and hypertension dose improve pulmonary function.Methods: We divided 25 rats into three groups.The rats were supplemented by gavage with:(Ⅰ)normal saline as control group(9);(Ⅱ)fish oil(0.3%,8) and(III)fish oil(0.6%,8).The cytokine levels were analyzed.The lungs were harvested,stained with hematoxylin-eosin,and analyzed. Results:Intra-abdominal sepsis and hypertension induced thickening of alveolar walls and inflammatory reaction.Fish oil decreased expression of pro-inflammatory cytokines(TNF-? and IL-1?),inhibitted infiltration of MPO positive cells,and protected pulmonary structure.Conclusion: The lung may be protected by an enteral fish oil nutrition through attenuating inflammatory reaction.
