Mucinous Cholangiocarcinoma associated with Clonorchis sinensis Infestation: A Case Report.
- Author:
Hyo Sup SHIM
1
;
Beom Jin LIM
;
Myeong Jin KIM
;
Woo Jung LEE
;
Chanil PARK
;
Young Nyun PARK
Author Information
1. Department of Pathology, Yonsei University College of Medicine, Seoul, Korea. young0608@yumc.yonsei.ac.kr
- Publication Type:Case Report ; English Abstract
- Keywords:
Cholangiocarcinoma;
Mucin;
Clonorchis sinensis
- MeSH:
Aged;
Bile Duct Neoplasms/*complications/secretion;
*Bile Ducts, Intrahepatic;
Cholangiocarcinoma/*complications/secretion;
Clonorchiasis/*complications;
English Abstract;
Humans;
Male;
Mucins/secretion
- From:The Korean Journal of Hepatology
2004;10(3):223-227
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mucinous cholangiocarcinoma, characterized by large quantities of mucin production, is a rare subtype of peripheral cholangiocarcinoma and usually shows rapid progression and a fatal outcome. We report here a case of mucinous cholangiocarcinoma in a 69 year-old man, who was infected with Clonorchis sinensis. Histologically, the tumor was an adenocarcinoma with extensive intracellular and extracellular mucin production, up to 70% of the tumor mass and there was frequent lymphovascular invasion of the tumor cells. The liver adjacent to the mass contained eggs of Clonorchis sinensis in the bile duct lumen and showed ductal epithelial hyperplasia, mucinous metaplasia and adenomatous proliferation of intramural glands. The patient was treated with a right hepatectomy. Four months after the surgery, the tumor recurred in the soft tissue of the right flank.
