Effect of QingreJiedu herbs in combination with Jiegeng decoction on expression of NF-?B p65 in ALI
- VernacularTitle:清热解毒药配伍桔梗汤对急性肺损伤大鼠肺核因子Kappa B p65蛋白表达的影响
- Author:
Fengjie ZHENG
;
Yuhang LI
;
Qingguo WANG
;
Lina LI
;
Ye JI
- Publication Type:Journal Article
- Keywords:
Acute lung injury;
Jiegeng decoction;
QingreJiedu;
Nuclear factor-kappa B;
Anti-in ammatory
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the e ect of QingreJiedu herbs in combination with Jiegeng decoction on expression of NF-?B p65 in ALI induced by LPS.Methods:Male Sprague-Dawley rats were randomly divided into normal group,model control group,QingreJiedu group,and the group of QingreJiedu herbs in combination with Jiegeng decoction.The model of ALI was made by injected with a single dose of LPS through vena femorali,the pathologic morphology,MPO activity and the expression of NF-?B p65 was observed.Result:Compared with normal group,infiltration.of PMNs,capillary congestion and swelling were found in model control group,and the content of MPO and expression of NF-?B p65 in the nuclear were significantly increased(P
