Experimental study on anti-tumor activity of total hedysarum polybotrys saccharide in vivo
- VernacularTitle:红芪总多糖体内抗肿瘤的实验研究
- Author:
Baotai YAO
;
Jianxiong ZHAO
;
Xuexi WANG
;
Fengfeng LEI
- Publication Type:Journal Article
- Keywords:
THPS;
Tumor-bearing mice;
T-lymphocyte subsets
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the suppressed e ects of total hedysarum polybotrys saccharide(THPS) alone and THPS combined with Cytoxan(CTX) on tumor-bearing mice and its mechanisms.Method:Kunming mice inoculated with S180 were given low,moderate and high dose THPS and THPS combined with CTX by intraperitoneal injection.Fourteen day later,tumor weight,inhibition rate,thymus index and spleen index were observed.CD4+ and CD8+ lymphocyte were counted though the ow cytometer.Results:Compared with the control,the moderate dose THPS showed signi cantly suppressed e ect on the growth of S180 tumor(P
