Prophylaxis of hepatic veno-occlusive disease after HSC transplantation with lipo-prostaglandin E1 plus dextran 40
- VernacularTitle:前列腺素E1脂质微球联合低分子右旋糖酐对造血干细胞移植后肝静脉闭塞病的预防作用分析
- Author:
Li FU
;
Weiping ZHANG
;
Jianmin WANG
- Publication Type:Journal Article
- Keywords:
prostaglandin(PGE1);
dextrans;
hematopoietic stem cell transplantion;
hepatic veno-occlusive disease
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of lipo-prostaglandin E1 plus dextran 40 in the prophylaxis of hepatic veno-occlusive disease(HVOD) after hematopoietic stem cell(HSC) transplantation.Methods Two hundred and thirty-four patients,162 males and 72 females,mean age 30.6(ranged from 3 to 64),were admitted during May 1999 to April 2007 and undergone HSC transplantation.Lipo-prostaglandin E1 associated with dextran 40 were administered to all patients for the prophylaxis of hepatic veno-occlusive disease.Lipo-prostaglandin E1,10?g dissolved in 100ml saline,20?g per day iv,were administered from day 7 before transplantation(-7 day) to day 30 after transplantation(+30 day).Dextran 40,500ml per day iv,were administered from-1 day to +5 day.In order to identify the risk factors inducing HVOD,patients were allocated to 2 groups according to following factors:age(
