Pathological Classification of Panaeatic Cancer and Precancerous Casion.
- Author:
Kee Taek JANG
1
Author Information
1. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ktjang@unitel.co.kr
- Publication Type:Review
- Keywords:
Pancreatic Neoplasms;
Carcinoma, Pancreatic Ductal;
Carinoma in Situ;
Precancerous Conditions
- MeSH:
Adenocarcinoma;
Adenocarcinoma, Mucinous;
Carcinoma, Pancreatic Ductal;
Carcinoma, Squamous Cell;
Classification*;
Duodenum;
Epithelium;
Hyperplasia;
Metaplasia;
Mucins;
Pancreas;
Pancreatic Ducts;
Pancreatic Neoplasms;
Phenobarbital;
Precancerous Conditions
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2004;8(3):127-132
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The ductal system of the pancreas, which is responsible for carrying acinar secretion to the duodenum, is perhaps the smallest epithelial component of the pancreas. However, most pancreatic tumors are of ductal origin, and a majority of these are ductal adenocarcinomas. Pancreatic carcinomas of ductal type can be separated into several categories: 1. Conventional ductal adenocarcinoma (tumors that form small tubular glands with luminal and intracellular mucin and are associated with marked stromal desmoplasia). 2. Unusual histological patterns of conventional ductal adenocarcinoma (e.g., foamy gland pattern, large duct pattern, vacuolated pattern, lobular carcinoma-like pattern). 3. Other carcinomas of ductal origin (e.g., colloid carcinoma, adenosquamous carinoma, squamous cell carcinoma, and undifferentiated carcioma). Most tumors in this last category usually have an associated component of conventional ductal adenocarcinoma, which provides evidence of their ductal origin. Precursors of pancreatic ductal adenocarcinoma have been recognized as proliferative epithelium of the ducts. Some lesions with minimal cytologic atypia were not regarded to be neoplastic and were designated hyperplasia or metaplasia, but molecular study revealed most ductal proliferative lesions as neoplastic. Thus the entire spectrum of ductal proliferative lesion is referred to as pancreatic intraepithelial neoplasia (PanIN).
