Studies on the relevance between HER-2 gene and tumorous microvessel density on the prognostic judgment of breast cancer
- VernacularTitle:HER-2原癌基因和肿瘤微血管密度对乳腺癌预后判断的一致性研究
- Author:
Lina LIU
;
Xiaobing LI
;
Bo ZHANG
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
HER-2 gene;
microvessel density;
in situ hybridization
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relevance among HER-2 gene amplification,microvessel density(MVD),tumor size,lymph node metastasis and histological grading,as well as to discuss the significance of the levels of HER-2 gene amplification and MVD on the prognostic judgment of breast cancer.Method From 2001 to 2005,30 breast cancer specimens were collected from the Affiliated Hospital of Academy of Military Medical Sciences.Coloring in situ hybridization(CISH) was used to examine HER-2 gene amplification in paraffin-embedded tissue samples.Microvessels in tissue were labeled by CD34 antibody using IHC,and the MVD was then counted under optical microscope.Result HER-2 gene amplification was found in 11 of 30 cases(36.7%).MVD in breast cancer samples with HER-2 gene amplification was 67.91?24.36,significantly higher than those samples without HER-2 gene amplification(47.48?13.27,P
