Efficacy and safety of caspofunjin on patients with refractory invasive fungal infections
- VernacularTitle:卡泊芬净治疗危重病难治性侵袭性真菌感染临床研究
- Author:
Xianghong YANG
;
Renhua SUN
;
Jun HONG
;
Bangchuan HU
;
Liang XU
- Publication Type:Journal Article
- Keywords:
caspofunjin;
invasive fungal infection
- From:
Chinese Journal of Practical Internal Medicine
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of Caspofunjin on invasive fungal infections in patients refractory to Fluconazole in ICU.Methods The open clinical trial was conducted in 44 invasive fungal infections patients who was refractory to Fluconazole,including 7 cases of confirmed,28 cases of suspected and 9 cases for empire treatment.They were treated with Caspofunjin in a dose of 70 mg in the first day,and then in a dose of 50 mg/d for 10～40 d.Results The cure rate of patients was 42.86%,the effective rate was 76.19%,and the eradication rate was 65.22%.All patients were well tolerated.Conclusion Caspofunjin is effective and safe in the treatment of severe invasive fungal infections.
