Phosphodiesterase 3:new targets for drug development
- VernacularTitle:磷酸二酯酶3:药物开发的新靶点
- Author:
Yilu YE
;
Qi ZHANG
;
Yueping YU
- Publication Type:Journal Article
- Keywords:
phosphodiesterase(PDE);
neuroprotection;
cerebral ischemia
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Phosphodiesterase(PDE) is hydrolase of 3',5'-cyclic adenosine monophosphate(cAMP) and 3',5'-cyclic guanosine monophosphate(cGMP).PDE3 are composed of two genes and distributed widely in vivo.Its inhibitors have been applied in antiplatelet aggregation and vasodilation.It has been reported that PDE3 inhibitors have neuroprotective effects on cerebral ischemia,which may provide new methods to prevention and therapy of cerebral ischemia.
