Correlation of HLA-DRB genetic locus with penicillin-specific IgE antibodies
- VernacularTitle:青霉素特异性IgE抗体的种类与HLA-DRB基因多态性
- Author:
Jing YANG
;
Hailing QIAO
- Publication Type:Journal Article
- Keywords:
allergy;
penicillin;
genetic polymorphism;
HLA-DRB;
IgE
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the correlation of positive specific IgE antibodies with penicillin allergy and HLA-DRB genetic polymorphism.Methods Sequence specific primer-polymerase chain reaction(PCR-SSP) was used to type human leucocyte antigen-DBR(HLA-DRB) alleles in 80 patients with positive IgE antibodies to penicillin and 101 healthy subjects without any allergic reactions.Results When different penicillin antigens were analyzed separately,the gene frequencies of DR16 in patients with positive BPO-IgE antibody and DR14.1 in patients with positive PVO-IgE antibody were found greatly lower than those of the control subjects(0 vs 8.62%,P
