Effect of L-Arg on myocardium in rat which suffered from limb ischemia-reperfusion
- VernacularTitle:L-精氨酸对大鼠肢体缺血/再灌注后心肌损伤的影响
- Author:
Lijun ZHAO
;
Xiuli MEN
;
Shuyun DONG
;
Xiaoyan KONG
;
Guoxian DUAN
;
Hongjie LI
;
Lianyuan ZHANG
- Publication Type:Journal Article
- Keywords:
L-arginine;
nitric oxide;
reperfusion injury;
myocardium
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of L-arginine(L-Arg) on myocardium in rat which suffered from limb ischemia-reperfusion.Methods Models of limb ischemia reperfusion were made by tourniquet methods.L-Arg(150 mg?kg-1) were intravascularly injected before reperfusion.Contents of malondialdehyde(MDA),myeloperoxidase(MPO) and tumour necrosis factor(TNF-?) in myocardium were measured.Levels of creatine kinase(CK),creatine kinase MB isoenzyme(CK-MB) and nitric oxide(NO) in plasma were deter-mined.The mean arterial pressure(MAP,left venteicular systolic pressure(LVSP),maximal rise rate of left venteicular pressure(dp/dtmax)and the maximal fall rate of left venteicular pressure(-dp/dtmax)were monitored.Morphologic changes of myocardium were evaluated after reperfusion.Results After rats' limbs suffering from ischemia-reperfusion,levels of MDA,MPO and TNF-? in myocardium,CK,CK-MB and NO in plasma increased differently(P
