Calpains and liver injury
- VernacularTitle:钙蛋白酶与肝损伤
- Author:
Yingnan YU
;
Yan LI
- Publication Type:Journal Article
- Keywords:
calpains;
liver;
injury
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Calpains are calcium-modulated proteases which respond to Ca2+ signals by removing limited portions of protein substrates,thereby irreversibly modifying their functions.Members of calpains are present in a variety of organisms in human.Calpains mediates crucial cellular functions,including rearrangement of cytoskeletal proteins and protein cleavage to activate various receptors and pro-enzymes.The abnormal activation of calpains is one of the important mechanisms in several pathogenesis,including neurodegenerative diseases,traumatic brain and spinal cord injuries,cataracts and ischemia-associated injuries.The recent findings on the role of calpains and its inhibitors in the liver injury will be reviewed in this paper.
