Expression of GRKs in synovial tissue from rats with collagen-induced arthritis and the effect of total glucosides of paeony
- VernacularTitle:胶原性关节炎大鼠滑膜组织G蛋白偶联受体激酶的表达及白芍总苷对其的影响
- Author:
Jingyu CHEN
;
Huaxun WU
;
Yin CHEN
;
Lingling ZHANG
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
collagen-induced arthritis;
GRKs;
total glucosides of paeony
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the expression of GRKs in rats of synovial tissue with collagen-induced arthritis(CIA) and the effect of total glucosides of paeony.Methods SD rats were divided into six groups including normal,model,TGP(25,50,100 mg?kg-1)groups,GTW(40 mg?kg-1)group.Chicken type Ⅱ collagen was used to induce CIA in rats.The expression of GRKs was detected by Westernblot.Results The expression of GRK2,5,6 increased in model group than that in normal group.Compared with the model group,the expression of GRK2,5,6 decreased in TGP groups.Conclusion In rats of synovial tissue with CIA,the expression of GRKs was abnormal,and TGP could change the variation of GRKs which may be one of the mechanisms of TGP improvement CIA.
